Reference level of serum urate for clinically evident incident gout
نویسندگان
چکیده
منابع مشابه
Eligibility for and prescription of urate-lowering treatment in patients with incident gout in England.
Eligibility for and Prescription of Urate-Lowering Treatment in PatientsWith Incident Gout in England Gout is caused by urate crystal deposition secondary to persistent hyperuricemia. Current guidelines recommenduratelowering treatment to prevent crystal deposition and encourage crystal dissolution for patients with more severe gout or concomitant conditions.1,2 However, after the first diagnos...
متن کاملIs serum urate causally associated with incident cardiovascular disease?
OBJECTIVE With studies reporting both positive and negative associations, the influence of serum urate on incident cardiovascular disease (CVD) is uncertain. We sought to determine whether serum urate is causally associated with incident CVD. METHODS Participants were aged 30-80 years and were screened for CVD risk in primary care between 2006 and 2009. Participants had blood pressure, lipids...
متن کاملGWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes
OBJECTIVE A genome-wide association study (GWAS) of gout and its subtypes was performed to identify novel gout loci, including those that are subtype-specific. METHODS Putative causal association signals from a GWAS of 945 clinically defined gout cases and 1213 controls from Japanese males were replicated with 1396 cases and 1268 controls using a custom chip of 1961 single nucleotide polymorp...
متن کاملCoevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout
Uric acid is the highly insoluble end-product of purine metabolism in humans. Serum levels exceeding the solubility threshold can trigger formation of urate crystals resulting in gouty arthritis. Uric acid is primarily excreted through the kidneys with 90% reabsorbed back into the bloodstream through the uric acid transporter URAT1. This reabsorption process is essential for the high serum uric...
متن کاملDetermination of serum haptoglobin reference value in clinically healthy Iranian fat-tailed sheep
Blood samples were collected from the jugular vein of 101 clinically healthy Iranian fat-tailed sheep according to their age (5 years) and sex. Serum haptoglobin (Hp) was measured based upon the preservation of the peroxidase activity of haemoglobin, which is directly proportional to the amount of Hp. The reference value for serum Hp of apparently healthy Iranian fat-tailed sheep was 0.05-0.18 ...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2018
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2018-213355